effects of probiotics with or without honey on radiation-induced diarrhea

نویسندگان

h.s. mansouri-tehrani department of biotechnology, university of isfahan, isfahan, iran

m. rabbani khorasgani department of biology, university of isfahan, isfahan, iran

m. roayaei department of radiation oncology, isfahan university of medical sciences, isfahan, iran

چکیده

background: diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. a popular alternative is probiotics, which have been used in several gastrointestinal disorders. probiotics are live microbial food supplements. furthermore, honey is a putative nutritional with a variety of health effects, including antibacterial, antioxidant, anti-inflammatory and prebiotic. the present study evaluated the effects of probiotic with or without honey on radiation-induced diarrhea. materials and methods: sixty-seven adult patients with pelvic cancer underwent radiotherapy for four weeks. they randomized to receive probiotic (n = 22), probiotic plus honey (n = 21) or placebo (n = 24) from one week before radiotherapy for five weeks. diarrhea grade and stool consistency score were recorded weekly according to the common toxicity criteria system and the bristol scales, respectively. results: the results showed a decrease in the daily number of bowel movements (p = 0.003 and 0.006), diarrhea grade (p = 0.001 and 0.001) and the need for antidiarrheal medication (p = 0.021 and 0.041) also an increase in the stool consistency (p = 0.004 and 0.005) in patients who either used probiotic or probiotic plus honey (respectively), these were significant in weeks 4 and 5 of treatment. conclusion: probiotics with or without honey can reduce the incidence of radiation-induced diarrhea and the need for antidiarrheal medication

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Effects of Probiotics with or without Honey on Radiation-induced Diarrhea

Background: Diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. A popular alternative is probiotics, which have been used in several gastrointestinal disorders. Probiotics are live microbial food supplements. Furthermore, honey is a putative nutritional with a variety of health effects, ...

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عنوان ژورنال:
iranian journal of radiation research

جلد ۱۴، شماره ۳، صفحات ۲۰۵-۲۱۳

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